PI3Kα Ligand-1
PI3Kα Ligand-1 is the ligand for PI3Kα that can be used for synthesis of PROTACs, such as PI3Kα degrader-1 (HY-174461) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; PI3K
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=S(NC1=C(N=CC(C2=CC3=C(N=CN=C3C(O)=C2)C)=C1)OC)(C4=CC=C(C=C4F)F)=O
Molecular Formula
C21H16F2N4O4S
Molecular Weight
458.44
References & Citations
[1]Peng S, et al. Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3-Kinase with Significant in Vivo Anticancer Efficacy. J Med Chem. 2025 Jun 26;68 (12) :12800-12818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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