Dione-piperidine-indazol-piperazin-cyclohexyl-NH2
Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand and linker. Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 can be used for synthesis of PROTAC MD-4251 (HY-174458).
Product Specifications
CAS Number
3052791-98-4
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Others
Smiles
CN1C2=CC(N(CC3)CCN3C[C@@H]4CC[C@@H](N)CC4)=CC=C2C(C5C(NC(CC5)=O)=O)=N1
Molecular Formula
C24H34N6O2
Molecular Weight
438.57
References & Citations
[1]Acharyya RK, et al. MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration. J Med Chem. 2025 Jul 10;68 (13) :13249-13267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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