Dione-piperidine-indazol-piperazin-cyclohexyl-NH2
Selected Variant
HY-174797
Size: 1 Each
Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand and linker. Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 can be used for synthesis of PROTAC MD-4251 (HY-174458).
Product Specifications
CAS Number
3052791-98-4
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Others
Smiles
CN1C2=CC(N(CC3)CCN3C[C@@H]4CC[C@@H](N)CC4)=CC=C2C(C5C(NC(CC5)=O)=O)=N1
Molecular Formula
C24H34N6O2
Molecular Weight
438.57
References & Citations
[1]Acharyya RK, et al. MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration. J Med Chem. 2025 Jul 10;68 (13) :13249-13267.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Price
Sign In for Pricing
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PA2279-APC 100 µg/Vial
Anti-Ras-related protein Rab-3C Rab3C Antibody Picoband®, APC Conjugate
Sign In for Pricing
View Details 
PA1303-FITC 100 µg/Vial
Anti-S100 beta/S100B Antibody Picoband®, FITC Conjugate
Sign In for Pricing
View Details 
PB9916-Cy3 100 µg/Vial
Anti-Apolipoprotein A I/APOA1 Antibody Picoband® (Cy3 Conjugate)
Sign In for Pricing
View Details 
BNC063732-100 1x 100 µL
Tubulin beta 3 / TUBB3 (Neuronal & Stem Cell Marker) (TUBB3/3732), CF405L conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470627-500 1x 500 µL
Cytokeratin 8 (TS1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC402898-500 1x 500 µL
CD71 / Transferrin Receptor (TFRC) (Extracellular Domain) (TFRC/2898R), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details