Dione-piperidine-indazol-piperazin-cyclohexyl-NH2

Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand (HY-W883326) and linker. Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 can be used for synthesis of PROTAC MD-4251 (HY-174458) [1].

Product Specifications

CAS Number

[3052791-98-4]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Field of Research

Others

Smiles

CN1C2=CC(N(CC3)CCN3C[C@@H]4CC[C@@H](N)CC4)=CC=C2C(C5C(NC(CC5)=O)=O)=N1

Molecular Formula

C24H34N6O2

Molecular Weight

438.57

References & Citations

[1]Acharyya RK, et al. MD-4251: A First-in-Class Oral MDM2 Degrader Inducing Complete Tumor Regression with Single-Dose Administration. J Med Chem. 2025 Jul 10;68 (13) :13249-13267.