E3 Ligase Ligand-linker Conjugate 195

E3 Ligase Ligand-linker Conjugate 195 is a conjugate of the CRBN ligand (HY-174470) and the linker. E3 Ligase Ligand-linker Conjugate 195 can be used for synthesis of PROTACs such as APH02174 (HY-174455) [1].

Product Specifications

CAS Number

[3065496-07-0]

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Related Pathways

PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

CN1C(C(N(C1=O)C2C(NC(CC2)=O)=O)=CC=C3)=C3C#CCO[C@@H](CC4)CC[C@H]4C=O

Molecular Formula

C23H25N3O5

Molecular Weight

423.46

References & Citations

[1]Wu XW, et al. Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Jun 26;68 (12) :12845-12861.