E3 Ligase Ligand-linker Conjugate 195
E3 Ligase Ligand-linker Conjugate 195 is a conjugate of the CRBN ligand and the linker. E3 Ligase Ligand-linker Conjugate 195 can be used for synthesis of PROTACs such as APH02174 (HY-174455).
Product Specifications
CAS Number
3065496-07-0
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
CN1C(C(N(C1=O)C2C(NC(CC2)=O)=O)=CC=C3)=C3C#CCO[C@@H](CC4)CC[C@H]4C=O
Molecular Formula
C23H25N3O5
Molecular Weight
423.46
References & Citations
[1]Wu XW, et al. Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Jun 26;68 (12) :12845-12861.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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