Gimeracil-13C3,15N

Gimeracil-13C3,15N (Gimestat-13C3,15N) is 13C and 15N labeled Gimeracil. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) [1][2].

Product Specifications

CAS Number

[1261394-32-4]

Product Name Alternative

Gimestat-13C3,15N

UNSPSC

12352005

Target

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[13C](C(Cl)=C[15NH]1)=[13CH][13C]1=O

Molecular Formula

C2 13C3H4Cl 15NO2

Molecular Weight

149.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Masakazu Fukushima, et al. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep. 2010 Nov;24 (5) :1307-13.|[3]Masaru Takagi, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96 (2) :259-66.|[4]Koh-Ichi Sakata, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep;102 (9) :1712-6.