HSP90i

HSP90i is a HSP90 inhibitor. HSP90i can be used as a drug intermediate to synthesize LYTACs, such as dPDL1-4 (HY-174468) [1][2].

Product Specifications

CAS Number

[1472616-48-0]

UNSPSC

12352208

Target

Drug Intermediate; HSP

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(C1=C(C=C(C(C2=NN=C(N2C3=CC=C(C=C3)CN4CCNCC4)O)=C1)O)O)C

Molecular Formula

C22H27N5O3

Molecular Weight

409.48

References & Citations

[1]Zhang D, et al. Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules. J Med Chem. 2025 Jun 26;68 (12) :12641-12657.|[2]Rastogi S, et al. An update on the status of HSP90 inhibitors in cancer clinical trials. Cell Stress Chaperones. 2024 Aug;29 (4) :519-539.