HDAC-IN-90
HDAC-IN-90 is the ligand for HDAC6/10 that can be used for synthesis of PROTAC HDAC degrader-2 (HY-174444) [1].
Product Specifications
CAS Number
[1354547-28-6]
UNSPSC
12352005
Target
HDAC; Ligands for Target Protein for PROTAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(NO)C(C=C1)=CC=C1CN2C3=CC=CC=C3C4=C2CCN(C(OC(C)(C)C)=O)C4
Molecular Formula
C24H27N3O4
Molecular Weight
421.49
References & Citations
[1]Zhai S, et al. Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders. J Med Chem. 2025 Jul 10;68 (13) :13793-13821.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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