IRAK4 ligand-14
IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455) [1].
Product Specifications
CAS Number
[3065496-26-3]
UNSPSC
12352005
Target
IRAK; Ligands for Target Protein for PROTAC
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Inflammation/Immunology
Smiles
OCC1CCN(CC1)C2=CC3=C(C=C2NC(C4=COC5=C4N=CC=C5)=O)CC6(CCNCC6)O3
Molecular Formula
C26H30N4O4
Molecular Weight
462.54
References & Citations
[1]Wu XW, et al. Discovery of APH02174 as a Highly Selective and Orally Bioavailable IRAK4 Degrader for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Jun 26;68 (12) :12845-12861.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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