PROTAC PI3K/110β degrader-2
PROTAC PI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. PROTAC PI3K/110β degrader-2 can significantly degrade 110β protein and inhibit the expression of P-glycoprotein. PROTAC PI3K/110β degrader-2 can increase the level of reactive oxygen species (ROS). PROTAC PI3K/110β degrader-2 exerts anti-tumor effects by activating the endoplasmic reticulum stress (ERS) -mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. PROTAC PI3K/110β degrader-2 can be used for research on cancer. (Pink: PI3K/110β Ligand ; Blue: VHL Ligand (HY-125845) ; Black: Linker (HY-W002042) ).
Product Specifications
CAS Number
3070438-79-5
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; Na+/K+ ATPase; P-glycoprotein; PI3K; PROTACs; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCNC(C4=CC=CC=C4NC(C)C5=CC(C)=CN6C5=NC(N7CCOCC7)=CC6=O)=O)=O)=O
Molecular Formula
C51H65N9O7S
Molecular Weight
948.18
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt; Bax; Bcl-2; PI3K
Frequently Asked Questions
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