PROTAC PI3K/110β degrader-2

PROTAC PI3K/110β degrader-2 is a selective PI3K/p110β PROTAC degrader. PROTAC PI3K/110β degrader-2 can significantly degrade 110β protein and inhibit the expression of P-glycoprotein. PROTAC PI3K/110β degrader-2 can increase the level of reactive oxygen species (ROS) . PROTAC PI3K/110β degrader-2 exerts anti-tumor effects by activating the endoplasmic reticulum stress (ERS) -mediated mitochondrial apoptosis pathway and inhibiting the AKT/Bcl-2 signaling pathway. PROTAC PI3K/110β degrader-2 can be used for research on cancer. (Pink: PI3K/110β Ligand (HY-75124) ; Blue: VHL Ligand (HY-125845) ; Black: Linker (HY-W002042) ) [1].

Product Specifications

CAS Number

[3070438-79-5]

UNSPSC

12352005

Target

Akt; Apoptosis; Bcl-2 Family; Na+/K+ ATPase; P-glycoprotein; PI3K; PROTACs; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; PROTAC

Field of Research

Cancer

Smiles

O=C(NCC1=CC=C(C=C1)C2=C(N=CS2)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCNC(C4=CC=CC=C4NC(C)C5=CC(C)=CN6C5=NC(N7CCOCC7)=CC6=O)=O)=O)=O

Molecular Formula

C51H65N9O7S

Molecular Weight

948.18

References & Citations

[1]Cen J, et al. Double Swords in One: Novel Selective PI3K/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp. J Med Chem. 2025 May 8;68 (9) :9446-9464.