DPDL1-4
DPDL1-4 is a potent and selective eHSPTAC eHSP90 PD-L1 degrader with DC50s of 7.77 μM and 6.52 μM in HeLa and B16F10 cells. dPDL1-4 bridges eHSP90 with the target protein, inducing lysosomal degradation. dPDL1-4 can degrade PD-L1 significantly and inhibits tumor growth. dPDL1-4 can be used for the study of cervical cancer and melanoma. ((Pink: eHSP90 ligand (HY-174476) ; Blue: PD-L1 ligand (HY-116274) ; Black: Linker (HY-W021787) ; HSP ligand + linker: HY-174799) ) [1].
Product Specifications
UNSPSC
12352005
Target
HSP; LYTACs; PD-1/PD-L1
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C1=C(C=C(C(C2=NN=C(N2C3=CC=C(C=C3)CN4CCN(CC4)C(CCOCCOCCOCCOCCNC(C5CCCCN5CC6=CC=C(OCC7=C(C(C8=CC=CC=C8)=CC=C7)C)C(Br)=C6)=O)=O)O)=C1)O)O)C
Molecular Formula
C60H74BrN7O10
Molecular Weight
1133.17
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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