5-HT2AR ligand 1
5-HT2AR ligand 1 (Compound 2 cis) is a 5-HT2AR ligand with nanomolar affinity for 5-HT2AR (Ki: 32 nM) . 5-HT2AR ligand 1 is capable of inducing β-arrestin 2 recruitment. 5-HT2AR ligand 1 can be used in the research of neurological diseases[1].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor; Arrestin
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
COC1=CC=C(/N=N\C2=CC=C(C3=C2)NC=C3CCNCC4=CC(OC)=CC=C4)C=C1
Molecular Formula
C25H26N4O2
Molecular Weight
414.50
References & Citations
[1]Sink A, et al. Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT2AR Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq. J Med Chem. 2025 Jun 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; Arrestin-3/β-Arrestin 2
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