5-HT2AR ligand 1

5-HT2AR ligand 1 (Compound 2 cis) is a 5-HT2AR ligand with nanomolar affinity for 5-HT2AR (Ki: 32 nM) . 5-HT2AR ligand 1 is capable of inducing β-arrestin 2 recruitment. 5-HT2AR ligand 1 can be used in the research of neurological diseases[1].

Product Specifications

UNSPSC

12352005

Target

5-HT Receptor; Arrestin

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

COC1=CC=C(/N=N\C2=CC=C(C3=C2)NC=C3CCNCC4=CC(OC)=CC=C4)C=C1

Molecular Formula

C25H26N4O2

Molecular Weight

414.50

References & Citations

[1]Sink A, et al. Design, Synthesis, and In Vitro Characterization of a Tryptamine-Based Visible-Light Photoswitchable 5-HT2AR Ligand Showing Efficacy Preference for β-Arrestin over Mini-Gq. J Med Chem. 2025 Jun 18.