PCR8

PCR8 is a prodrug of CR8 (HY-18340) . pCR8 is amphiphilic and can self-assemble into nanoparticles. pCR8 can release CR8 under the action of high concentration of H2O2 in the tumor microenvironment. CR8 is a molecular glue degrader that can effectively degrade cell cycle-related proteins and has antitumor activity. pCR8 can be used in the research of tumors such as breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Cancer

Smiles

CC[C@@H](COC(OCC1=CC=C(B(O)O)C=C1)=O)NC2=NC(NCC(C=C3)=CC=C3C4=CC=CC=N4)=C(N=CN5C(C)C)C5=N2

Molecular Formula

C32H36BN7O5

Molecular Weight

609.48

References & Citations

[1]Zhang N, et al. Self-Assembled Molecular Glue Prodrug System for Enhanced Synergistic Tumor Therapy by Combining CDK12 Protein Degradation and Immunotherapy. ACS Appl Mater Interfaces. 2025 Jul 2;17 (26) :37435-37447.