STAT3/CAIX-IN-1
STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM) . STAT3/CAIX-IN-1 induces ferroptosis by increases the levels of reactive oxygen species (ROS) and lipid peroxides. STAT3/CAIX-IN-1 inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 can be used for the study of triple-negative breast cancer (TNBC) [1].
Product Specifications
CAS Number
3053583-60-8
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Carbonic Anhydrase; Caspase; Ferroptosis; Reactive Oxygen Species (ROS) ; STAT
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=NN=C(S(=O)(N)=O)S1)CCCC(N2C/C(C(/C(C2)=C/C3=CC=C(C(F)(F)F)C=C3)=O)=C\C4=CC=C(C(F)(F)F)C=C4)=O
Molecular Formula
C28H23F6N5O5S2
Molecular Weight
687.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA; CA II; CA IX; STAT3
Frequently Asked Questions
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