APH02174
APH02174 is a highly selective and orally active IRAK4 PROTAC degrader with the DC50 of 4.01 nM in THP-1 cells. APH02174 blocks inflammatory signals by inhibiting IL-6 release. APH02174 can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis. (Pink: IRAK4 Ligand (HY-174470) ; Blue: CRBN Ligand (HY-45512) ; Black: Linker; CRBN Ligand+Linker (HY-174796) ) [1]
Product Specifications
CAS Number
[3065494-66-5]
UNSPSC
12352005
Target
Interleukin Related; IRAK; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OCC1CCN(CC1)C2=CC3=C(C=C2NC(C4=COC5=C4N=CC=C5)=O)CC6(CCN(CC6)C[C@@H]7CC[C@@H](OCC#CC8=C(C(N(C9=O)C%10C(NC(CC%10)=O)=O)=CC=C8)N9C)CC7)O3
Molecular Formula
C49H55N7O8
Molecular Weight
870.00
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; IRAK4
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