Antitrypanosomal agent 24
Antitrypanosomal agent 24 is a benzothiazole amidoxime with strong and selective antitrypanosomal activity (IC50 = 0.92 μM) . Antitrypanosomal agent 24 is a substrate of the P-glycoprotein efflux pump. Antitrypanosomal agent 24 has high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA by intercalation[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
N/C(C1=CC=C2C(SC(C3=CC=C(OCCN(CC)CC)C(F)=C3)=N2)=C1)=N\O
Molecular Formula
C20H23FN4O2S
Molecular Weight
402.49
References & Citations
[1]Kaulić, V. R., et al., (2025) . Syntheses of benzothiazole amidoximes and arylimidamides and evaluation of their ADME and DNA binding properties and activity against Trypanosoma brucei. European journal of medicinal chemistry, 296, 117854. Advance online publication.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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