PROTAC ERα Degrader-12
PROTAC ERα Degrader-12 is a potent and selective Erα PROTAC degrader. PROTAC ERα Degrader-12 has antiproliferative effects in multiple breast cancer cell lines with wild-type or mutant ERα. PROTAC ERα Degrader-12 can halt the cell cycle and induce cell apoptosis. PROTAC ERα Degrader-12 exhibits excellent antitumor and ERα degradation activity. PROTAC ERα Degrader-12 can be used for research on breast cancer. (Pink: ER ligand-11 ; Blue: VHL ligand (HY-112078) ; Black: Linker (HY-W088749) ; VHL ligand + Linker (HY-W998310) ).
Product Specifications
UNSPSC
12352100
Target
Apoptosis; Estrogen Receptor/ERR; PROTACs
Related Pathways
Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C)([C@H](NC(CCCCC(NCC1=C(C(CN)=C(C(CN)=C1CCCCC)CCCCC)CCCCC)=O)=O)C(N2C[C@H](O)C[C@H]2C(N[C@H](C3=CC=C(C=C3)C4=C(C)N=CS4)C)=O)=O)C
Molecular Formula
C53H83N7O5S
Molecular Weight
930.34
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; von Hippel-Lindau (VHL)
Frequently Asked Questions
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