PROTAC ERα Degrader-12

PROTAC ERα Degrader-12 is a potent and selective Erα PROTAC degrader. PROTAC ERα Degrader-12 has antiproliferative effects in multiple breast cancer cell lines with wild-type or mutant ERα. PROTAC ERα Degrader-12 can halt the cell cycle and induce cell apoptosis. PROTAC ERα Degrader-12 exhibits excellent antitumor and ERα degradation activity. PROTAC ERα Degrader-12 can be used for research on breast cancer. (Pink: ER ligand-11 (HY-174475) ; Blue: VHL ligand (HY-112078) ; Black: Linker (HY-W088749) ; VHL ligand + Linker (HY-W998310) ) [1].

Product Specifications

UNSPSC

12352100

Target

Apoptosis; Estrogen Receptor/ERR; PROTACs

Related Pathways

Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC(C)([C@H](NC(CCCCC(NCC1=C(C(CN)=C(C(CN)=C1CCCCC)CCCCC)CCCCC)=O)=O)C(N2C[C@H](O)C[C@H]2C(N[C@H](C3=CC=C(C=C3)C4=C(C)N=CS4)C)=O)=O)C

Molecular Formula

C53H83N7O5S

Molecular Weight

930.34

References & Citations

[1]Wang Y, et al. Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS) . J Med Chem. 2025 Jul 10;68 (13) :13640-13660.