ADP-ribose/PARP-IN-1

ADP-ribose/PARP-IN-1 (Compound Ex.16) is a conjugated compound. ADP-ribose/PARP-IN-1 contains disease targeting moieties, PARP inhibitor moieties, cleavable linkers, chelators. ADP-ribose/PARP-IN-1 targets specific targets through the disease targeting moiety and selectively delivers PARP inhibitors to tumor cells. The cleavable linker of ADP-ribose/PARP-IN-1 releases the PARP inhibitor under appropriate conditions, inhibiting PARP to prevent DNA damage repair, while the radionuclide carried by the chelator exerts a killing effect. ADP-ribose/PARP-IN-1 can be used in the research of prostate cancer[1].

Product Specifications

CAS Number

[3047557-92-3]

UNSPSC

12352005

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CN(C)C(CCCCCCC(NCCCC[C@@H](NC(CCC(N5CCN(CCN(CCN(CC5)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)C(N[C@H](CC(O)=O)C(NCCC(NC[C@@H]6CC[C@H](CC6)C(N[C@H](C(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC7=CC8=C(C=CC=C8)C=C7)=O)=O)=O)=O)=O)=O)NC3=CC(F)=C2

Molecular Formula

C92H125FN16O26

Molecular Weight

1890.07

References & Citations

[1]Zhou X, et al. Targeted Treatment of Cancer by Using Conjugate Compounds with Poly (ADP-ribose) Polymerase (PARP) Inhibitors. ACS Medicinal Chemistry Letters, 2025.