PARP1-IN-39

PARP1-IN-39 is an inhibitor of PARP1 with an IC50 of 0.22 nM. PARP1-IN-39 has an IC50 of 1.57 nM in human breast cancer cells. PARP1-IN-39 can be studied in breast, ovarian, pancreatic, and prostate cancers associated with DNA repair deficiencies, such as BRCA1/2 mutations[1].

Product Specifications

CAS Number

[3054988-47-2]

UNSPSC

12352005

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CCNC(C1=CC=C(N2C=C3CN(CC3=N2)CC4=C(C5=C(N6N=CC(F)=C6C(N5)=O)C=C4)F)C(F)=N1)=O

Molecular Formula

C24H19F3N8O2

Molecular Weight

508.46

References & Citations

[1]Xin Zhou and Steven H. Liang (2025) . Synthesis of Novel Substituted N-Heterocycles and Their Use of Selective Poly (ADP-ribose) Polymerase 1 (PARP1) Inhibitors. ACS Med. Chem. Lett. 2025, 16, 7, 1254–1255.