PROTAC sEH degrader-2

PROTAC sEH degrader-2 is a PROTAC targeting degradation agent for soluble epoxide hydrolase (sEH) with pIC50 values of the catalytic domain of 8.37 (human sEH-H) and 7.12 (mouce sEH-H) . PROTAC sEH degrader-2 can be used for the research related to inflammation and neuroinflammation, such as Alzheimer's disease[1]. (Structure Note: Pink: sEH-H ligand (HY-174225) ; Blue: CRBN Ligand (HY-103597) ; Black: linker; E3 + linker (HY-141011) )

Product Specifications

UNSPSC

12352100

Target

Epoxide Hydrolase; PROTACs

Related Pathways

Metabolic Enzyme/Protease; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

O=C(NCC1=C(C=C(C=C1)NS(=O)(CCCC2=CN(N=N2)CCOCCOCCOCCOCCNC(COC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)=O)C(F)(F)F)C6=CC=C7N(C=CC7=C6)CC8=CC=CC(F)=C8

Molecular Formula

C54H57F4N9O13S

Molecular Weight

1148.14

References & Citations

[1]Schönfeld J, et al. Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. J Med Chem. 2025 Jul 10;68 (13) :13728-13749.