PARP1-IN-40
PARP1-IN-40 is a highly selectively and orally active PARP1 inhibitor (IC50: 0.19 nM for PARP1, 26 nM for PARP2) . PARP1-IN-40 kills tumor cells by inhibiting PARP1, leading to accumulation of DNA damage. PARP1-IN-40 has high antitumor activity against BRCA mutant MDA-MB-436 cells. PARP1-IN-40 can be used in combination with chemotherapy for cancer-related research[1].
Product Specifications
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CNC(C1=CC=C(C=N1)C2=CCN(C[C@H]2C)CC3=CC4=C(N5C=CC(F)=C5C(N4)=O)C=C3)=O
Molecular Formula
C25H24FN5O2
Molecular Weight
445.49
References & Citations
[1]Tao Guo, et al. Discovery and Pharmacological Evaluation of Potent and Highly Selective PARP1 Inhibitors. J Med Chem. 2025 Jul 10. 68 (13) :13491-13515.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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