Nsp12-IN-2

Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses[1].

Product Specifications

CAS Number

[667882-55-5]

UNSPSC

12352005

Target

Drug Metabolite; SARS-CoV; Virus Protease

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(N([C@@H]1S[C@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@@H](O)[C@H]1O)C=C2)NC2=O

Molecular Formula

C9H12N2Na3O14P3S

Molecular Weight

566.15

References & Citations

[1]Kim M, et al. Identification of 4'-Thiouridine as an Orally Available Antiviral Agent Targeting Both RdRp and NiRAN Functions of SARS-CoV-2 Nsp12. J Med Chem. 2025 Jun 26;68 (12) :12414-12433.