FLT3-IN-32 (TFA)

FLT3-IN-32 TFA is a potent FLT3 inhibitor with an IC50s of 2.40 nM and 3.83 nM against FLT3-ITD and FLT3-D835Y. FLT3-IN-32 TFA inhibits proliferation/survival of human MV4-11 cells with an IC50 of 0.07 nM. FLT3-IN-32 TFA can be used for the study of acute myeloid leukemia (AML) [1].

Product Specifications

CAS Number

[3047195-49-0]

UNSPSC

12352005

Target

FLT3

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC1=CC2=C(OC(C(C3=CC4=C(CN(C)C)C(O)=CC=C4N3)=O)=C2)C=C1)NC5=NOC(C(C)(C)C)=C5.O=C(O)C(F)(F)F

Molecular Formula

C30H30F3N5O7

Molecular Weight

629.58

References & Citations

[1]Sellmer A, et al. Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3) . Eur J Med Chem. 2025 Oct 15;296:117849.