FLT3-IN-32

FLT3-IN-32 is a potent and orally active FLT3 inhibitor. FLT3-IN-32 shows high selectivity for FLT3 and efficiently inhibits FLT3-activating mutations and induces apoptosis. FLT3-IN-32 shows good tolerability in non-tumor bearing mice. FLT3-IN-32 demonstrates outstanding anti-tumor efficacy in MV4-11 bearing NOD/SCID mice, prolonging the survival noticeably. FLT3-IN-32 can be used for the research of acute myeloid leukemia[1].

Product Specifications

CAS Number

[3047195-48-9]

UNSPSC

12352005

Target

Apoptosis; FLT3

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(OC(C(C(N2)=CC3=C2C=CC(O)=C3CN(C)C)=O)=C4)C4=C1)NC5=NOC(C(C)(C)C)=C5

Molecular Formula

C28H29N5O5

Molecular Weight

515.56

References & Citations

[1]Sellmer A, et al. Novel water-soluble and highly efficient dual type I/II next generation inhibitors of FMS-like tyrosine kinase 3 (FLT3) . Eur J Med Chem. 2025 Jun 8;296:117849.