FLT3-IN-32
FLT3-IN-32 is a potent and orally active FLT3 inhibitor. FLT3-IN-32 shows high selectivity for FLT3 and efficiently inhibits FLT3-activating mutations and induces apoptosis. FLT3-IN-32 shows good tolerability in non-tumor bearing mice. FLT3-IN-32 demonstrates outstanding anti-tumor efficacy in MV4-11 bearing NOD/SCID mice, prolonging the survival noticeably. FLT3-IN-32 can be used for the research of acute myeloid leukemia[1].
Product Specifications
CAS Number
[3047195-48-9]
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(OC(C(C(N2)=CC3=C2C=CC(O)=C3CN(C)C)=O)=C4)C4=C1)NC5=NOC(C(C)(C)C)=C5
Molecular Formula
C28H29N5O5
Molecular Weight
515.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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