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ABCB1/ABCG2-IN-1

ABCB1/ABCG2-IN-1 (Compound (S, Z) -4b) is an inhibitor of ABCB1 and ABCB2 transporters. ABCB1/ABCG2-IN-1 shows moderate activity in SW620M, -V, and –Mito variants (IC50 ≈ 50 μM) . ABCB1/ABCG2-IN-1 affects methotrexate resistance in vitro. ABCB1/ABCG2-IN-1 can be studied in anticancer research[1].

Product Specifications

UNSPSC

12352005

Target

P-glycoprotein

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

O=C([C@@]1(CCCN1C/2=O)[H])NC2=C/C3=C(c4cccc4)C=CC=C3.[][Fe][].c5cccc5

Molecular Formula

C24H22FeN2O2

Molecular Weight

426.29

References & Citations

[1]Andrzej Błauż, et al., (2025) . Design, Synthesis, and Biological Evaluation of Ferrocenyl–Cyclo- (Gly-l-Pro) Hybrids Sensitizing Multidrug-Resistant Cancer Cells to Anticancer Agents. ACS Med. Chem. Lett. 2025, 16, 7, 1391–1400

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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