PAN endonuclease-IN-3

PAN endonuclease-IN-3 is a potent PAN endonuclease inhibitor that against influenza virus polymerase complexes with an IC50 of 17.4 nM. PAN endonuclease-IN-3 demonstrates potent inhibitory activities against PAN endonuclease. PAN endonuclease-IN-3 demonstrates robust antiviral activities against multiple current and different influenza virus strains while showing minimal cytotoxicity in MDCK cells. PAN endonuclease-IN-3 significantly suppresses viral replication in an A/WSN/33 infected mouse model[1].

Product Specifications

UNSPSC

12352005

Target

Endonuclease; Influenza Virus

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

CC(C)N(C1(COC1)N([C@@H]2C3=C(SCC4=C(C(F)=CC=C42)F)C=CC=C3)N5C=C6)C(C5=C(O)C6=O)=O

Molecular Formula

C26H23F2N3O4S

Molecular Weight

511.54

References & Citations

[1]Liu S, et al. Design and Synthesis of PAN Endonuclease Inhibitors through Spirocyclization Strategy against Influenza A Virus. J Med Chem. 2025 Jun 18.