RN341
RN341 is a specific type II kinase inhibitor of LRRK2 (IC50: 296 nM) . RN341 inhibits LRRK2 phosphorylation and avoids S935 dephosphorylation by stabilizing the open conformation. RN341 rescues LRRK2-mediated kinesin motility block by preventing microtubule binding. RN341 effectively inhibits LRRK2 wild-type and G2019S mutant at the cellular level. RN341 provides a new direction for Parkinson's disease research[1].
Product Specifications
UNSPSC
12352005
Target
LRRK2
Related Pathways
Autophagy
Field of Research
Neurological Disease
Smiles
O=C(NC1=CC(C(C)(C)C)=NN1C2=CC=C(C)C=C2)NC3=CC(C4=CNC5=NC(SCC)=NC(NC)=C54)=CC=C3
Molecular Formula
C30H34N8OS
Molecular Weight
554.71
References & Citations
[1]Nicolai D. Raig, et al. Type II kinase inhibitors that target Parkinson's disease-associated LRRK2. BioRxiv. 2025 Feb 13. 2024.09.17.613365.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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