CYP1B1-IN-9
CYP1B1-IN-9 is a highly selective and competitive CYP1B1 Inhibitor with IC50 values of 1.48 nM, > 100 μM, and > 80 μM for CYP1B1, CYP1A1, and CYP1A2, respectively. CYP1B1-IN-9 significantly inhibits the migration and invasion of A549/T cells. CYP1B1-IN-9 has the ability to resensitize Paclitaxel (HY-B0015) -resistant cells, and good metabolic stability and safety, and shows favorable pharmacokinetic parameters. CYP1B1-IN-9 can be used for the study of tumor-drug resistance[1].
Product Specifications
CAS Number
[3077254-39-5]
UNSPSC
12352100
Target
Cytochrome P450
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=NC(C2=CC=CC(Cl)=C2)=CS1)NC3=CC(Cl)=CC(Cl)=C3
Molecular Formula
C16H9Cl3N2OS
Molecular Weight
383.68
References & Citations
[1]Wang T, et al. Discovery of Highly Selective CYP1B1 Inhibitors. J Med Chem. 2025 Jun 26;68 (12) :13089-13112.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1
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