FAPI-JNU
FAPI-JNU is a molecule targeting fibroblast activation protein (FAP) . FAPI-JNU specifically binds to FAP highly expressed in the tumor microenvironment, and uses radionuclides [68Ga]Ga or [177Lu]Lu to achieve tumor imaging diagnosis. [177Lu]Lu−FAPI−JNU can effectively target and inhibit tumor growth in tumor-bearing mice. FAPI-JNU is promising for research of FAP-positive tumors (such as various solid tumors) [1].
Product Specifications
UNSPSC
12352005
Target
FAP
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(CN(CCN(CC(N[C@H](C(N[C@H](C(NCCOCCOCCOCCOCC(N1CCN(CC1)CCCN(C2=CC=C(C3=C2)N=CC=C3C(NCC(N4CC(F)(C[C@]4(C#N)[H])F)=O)=O)C)=O)=O)CCCCNC(CCCC5=CC=C(C=C5)O)=O)=O)CCC(NCCOCCOCCOCCOCC(N6CCN(CC6)CCCN(C7=CC=C(C8=C7)N=CC=C8C(NCC(N9CC(F)(C[C@]9(C#N)[H])F)=O)=O)C)=O)=O)=O)CCN(CC%10)CC(O)=O)CCN%10CC(O)=O)O
Molecular Formula
C107H153F4N23O26
Molecular Weight
2253.49
References & Citations
[1]Luo Y, et al. Rational Design and Preliminary Evaluation of a Radiopharmaceutical Targeting Fibroblast Activation Proteins [68Ga]Ga/[177Lu]Lu-FAPI-JNU for Tumor Imaging and Therapy. J Med Chem. 2025 Jun 26;68 (12) :12745-12755.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-174421/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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