NNRT-IN-10

NNRT-IN-10 is a potent, selective and orally active non-nucleoside HIV-1 reverse transcriptase (NNRTI) inhibitor with with an EC50 values ranging from 1.16 to 18.3 nM for HIV and its mutant strains. NNRT-IN-10 exhibits good pharmacokinetic properties and favorable safety profiles. NNRT-IN-10 can be used for the study of AIDS, caused by HIV-1[1].

Product Specifications

CAS Number

[2459751-62-1]

UNSPSC

12352005

Target

Cytochrome P450; HIV; Potassium Channel; Reverse Transcriptase

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

CC1=CC(/C=C/C#N)=CC(C)=C1OC2=C(C=CC=N3)C3=NC(NC4CCN(CC5=CC=C(S(C)(=O)=O)C=C5)CC4)=N2

Molecular Formula

C31H32N6O3S

Molecular Weight

568.69

References & Citations

[1]Li W, et al. A nanoparticle-encapsulated non-nucleoside reverse-transcriptase inhibitor with enhanced anti-HIV-1 activity and prolonged circulation time in plasma. Curr Pharm Des. 2015;21 (7) :925-35.