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Smurf1-IN-5

Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) [1].

Product Specifications

CAS Number

1824647-09-7

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Smiles

FC1=CC=CC=C1N2C(C(NC(C3=NOC(C4=CC=C(C5CC5)C=C4Cl)=C3C)=O)=C(C)N2C)=O

Molecular Formula

C25H22ClFN4O3

Molecular Weight

480.92

References & Citations

[1]Rothman AMK, et al. Therapeutic potential of allosteric HECT E3 ligase inhibition. Cell. 2025 May 15;188 (10) :2603-2620.e18.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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