Smurf1-IN-5
Smurf1-IN-5 (Compound cpd-6) is an allosteric SMAD ubiquitin regulatory factor 1 (SMURF1) inhibitor. Smurf1-IN-5 leads to a reduction in the ubiquitylation of substrates such as BMPR2 (bone morphogenetic protein receptor 2) and SMAD1, enhancing the BMP (bone morphogenetic protein) signaling pathway. Smurf1-IN-5 is promising for research of pulmonary arterial hypertension (PAH) [1].
Product Specifications
CAS Number
[1824647-09-7]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
FC1=CC=CC=C1N2C(C(NC(C3=NOC(C4=CC=C(C5CC5)C=C4Cl)=C3C)=O)=C(C)N2C)=O
Molecular Formula
C25H22ClFN4O3
Molecular Weight
480.92
References & Citations
[1]Rothman AMK, et al. Therapeutic potential of allosteric HECT E3 ligase inhibition. Cell. 2025 May 15;188 (10) :2603-2620.e18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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