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Tubulin polymerization-IN-82

Tubulin polymerization-IN-82 is a tubulin inhibitor. Tubulin polymerization-IN-82 inhibits cell migration and invasion, and triggers cell apoptosis through the mitochondria and ER stress mediated pathway. Tubulin polymerization-IN-82 exhibits antitumor activity against drug resistance cancer cells, and inhibits tumor growth, can be used for liver cancer research[1].

Product Specifications

CAS Number

3067075-77-5

UNSPSC

12352005

Target

Bcl-2 Family; Caspase; Microtubule/Tubulin; MMP; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(/C=C/C1=CC=C(OC)C=C1)OCCOC2=CC(/C=C\C3=CC(OC)=C(OC)C(OC)=C3)=CC=C2OC

Molecular Formula

C30H32O8

Molecular Weight

520.57

References & Citations

[1]Huang X, et al. Discovery of novel combretastatin A4 derivatives as a microtubule targeting agent capable of inducing HepG-2 cell apoptosis via the mitochondria and ER stress mediated pathway. Bioorg Chem. 2025 Jun 6;163:108676.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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