MT-125 (free base)
MT-125 free base is a specific and well-tolerated inhibitor of non-muscle myosin IIA (Ki, NMIIA = 2.7 μM) and IIB (EC50 = 1.7 μM) . MT-125 free base can pass through the blood-brain barrier. MT-125 free base induces ferroptosis and DNA damage by increasing the levels of reactive oxygen species (ROS) within tumor cells. MT-125 free base can enhance the PDGFR signaling pathway. MT-125 free base can be used for research on glioblastoma[1].
Product Specifications
CAS Number
2404652-80-6
UNSPSC
12352005
Target
Akt; ERK; Ferroptosis; mTOR; Myosin; PDGFR; Reactive Oxygen Species (ROS)
Related Pathways
Field of Research
Cancer; Inflammation/Immunology
Purity
98.6600
Smiles
CC1=CC2=C(N=C(N(C3=CC4=C(N=C(C)C=C4)C=C3)CC5)[C@]5(O)C2=O)C=C1
Molecular Formula
C22H19N3O2
Molecular Weight
357.41
References & Citations
[1]Kenchappa RS, et al. MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma. Cell. 2025 Jun 3:S0092-8674 (25) 00569-0.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDGFRα
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human Papillomavirus 16 (HPV-16) (HPV16/1058), CF594 conjugate, 0.1mg/mL
