PROTAC HDAC6 degrader 5
PROTAC HDAC6 degrader 5 (Compound 5a) is a highly selective PROTAC targeting HDAC6. PROTAC HDAC6 degrader 5 can effectively degrade HDAC6 in cells (IC50 = 43 nM) . PROTAC HDAC6 degrader 5 reduces HDAC6 levels through proteasome- and CRBN-dependent mechanisms (Pink: Target protein ligand (HY-174408), Target protein ligand + linker (HY-174409) ; Blue: Pomalidomide (HY-10984), Pomalidomide 4'-alkylC3-azide (HY-139341) ) [1].
Product Specifications
UNSPSC
12352100
Target
HDAC; Ligands for E3 Ligase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(NO)C1=CC=C(CN2C(C3=CC=CN=C3)C(C)(C)C4=C2C=CC(NC(CCCOCC5=CN(CCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)N=N5)=O)=C4)C=C1
Molecular Formula
C47H50N10O9
Molecular Weight
898.96
References & Citations
[1]Ilaria Cursaro, et al. Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC8
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