GSK-3β/HDAC-IN-2
GSK-3β/HDAC-IN-2 is a potent inhibitor of GSK-3β (IC50 = 0.04 μM), HDAC2 (IC50 = 1.05 μM, Ki = 0.070 μM) and HDAC6 (IC50 = 1.52 μM, Ki = 0.017 μM) . GSK-3β/HDAC-IN-2 inhibits HDAC2 and HDAC6 activities and blocks tau hyperphosphorylation. GSK-3β/HDAC-IN-2 exerts neuroprotective effects and shows no significant toxicity. GSK-3β/HDAC-IN-2 can be used in the research of Alzheimer's disease[1].
Product Specifications
UNSPSC
12352100
Target
GSK-3; HDAC; Tau Protein
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(NO)C1=CC=C(CNC(NC2=NC=C([N+]([O-])=O)S2)=O)C=C1
Molecular Formula
C12H11N5O5S
Molecular Weight
337.31
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β; HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Frequently Asked Questions
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