AR antagonist 15

AR antagonist 15 is an orally active androgen receptor (AR) antagonist with the IC50 of 97 nM for ART787A. AR antagonist 15 disrupts AR nuclear translocation, hinders AR homodimerization, and suppresses transcription of AR-regulated genes by competitive binding to the ligand binding pocket. AR antagonist 15 can significantly lower the prostate-specific antigen (PSA) level. AR antagonist 15 induces apoptosis by reducing the expression of apoptosis pathway related proteins. AR antagonist 15 can be used for the research of prostate cancer[1].

Product Specifications

CAS Number

[1790308-86-9]

UNSPSC

12352005

Target

Androgen Receptor; Apoptosis

Related Pathways

Apoptosis; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(NC1=CC=C(C=C1)OCC2=CC=CC=C2)(N3CCCCC3)=O

Molecular Formula

C18H22N2O3S

Molecular Weight

346.44

References & Citations

[1]Chai X, et al. Unraveling the Efficacy of AR Antagonists Bearing N- (4- (Benzyloxy) phenyl) piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations. J Med Chem. 2025 Jun 12;68 (11) :11962-11978.