KIN-8741

KIN-8741 is a highly selective Type IIb c-Met inhibitor. KIN-8741 has broad activity against c-Met kinase mutations. KIN-8741 shows antitumor activity in MET gene amplified and exon 14 deleted non-small cell lung cancer models. KIN-8741 can be used in the research of c-Met driven cancers, especially advanced tumors carrying MET exon 14 jump mutations, acquired drug resistance mutations, etc[1].

Product Specifications

CAS Number

[2941104-53-4]

UNSPSC

12352005

Target

C-Met/HGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

FC1=CC(NC(C2=C(C=CN=C2)OC)=O)=CC(F)=C1OC3=CC=NC4=CC(OC)=C(C=C43)O[C@H](CO)C

Molecular Formula

C26H23F2N3O6

Molecular Weight

511.47

References & Citations

[1]Ouyang XS, et al. Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer. J Med Chem. 2025 Jun 12;68 (11) :10648-10662.