KIN-8741
KIN-8741 is a highly selective Type IIb c-Met inhibitor. KIN-8741 has broad activity against c-Met kinase mutations. KIN-8741 shows antitumor activity in MET gene amplified and exon 14 deleted non-small cell lung cancer models. KIN-8741 can be used in the research of c-Met driven cancers, especially advanced tumors carrying MET exon 14 jump mutations, acquired drug resistance mutations, etc[1].
Product Specifications
CAS Number
[2941104-53-4]
UNSPSC
12352005
Target
C-Met/HGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
FC1=CC(NC(C2=C(C=CN=C2)OC)=O)=CC(F)=C1OC3=CC=NC4=CC(OC)=C(C=C43)O[C@H](CO)C
Molecular Formula
C26H23F2N3O6
Molecular Weight
511.47
References & Citations
[1]Ouyang XS, et al. Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer. J Med Chem. 2025 Jun 12;68 (11) :10648-10662.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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