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STAT3-IN-43

STAT3-IN-43 (Compound K2) is a covalent inhibitor targeting the allosteric site at the junction of the STAT3 coiled-coil domain and DNA-binding domain, with an IC50 of 40.7 μM. STAT3-IN-43 can be used in cancer research[1].

Product Specifications

CAS Number

2761657-21-8

UNSPSC

12352005

Target

STAT

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

BrC1=CC(CNC(C2CCCN(C(C=C)=O)C2)=O)=CC3=C1OCO3

Molecular Formula

C17H19BrN2O4

Molecular Weight

395.25

References & Citations

[1]Szalai TV, et al. Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening. ACS Med Chem Lett. 2025 May 6;16 (6) :991-997.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3

Frequently Asked Questions

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