TREM2 agonist-4

TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1].

Product Specifications

UNSPSC

12352100

Target

TREM receptor

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=C1CC(C1)C(NC2=CC(C(NC)=O)=CC(C3=C(CCCCCCCC)C=CS3)=C2OC)=O

Molecular Formula

C27H36N2O3S

Molecular Weight

468.65

References & Citations

[1]Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.