TREM2 agonist-4
TREM2 agonist-4 (Compound 4a) is a TREM2 agonist with a Kd value of 45.9 μM. TREM2 agonist-4 can activate downstream signaling pathways of TREM2 and enhance the phagocytic function of microglia. TREM2 agonist-4 can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1].
Product Specifications
UNSPSC
12352100
Target
TREM receptor
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=C1CC(C1)C(NC2=CC(C(NC)=O)=CC(C3=C(CCCCCCCC)C=CS3)=C2OC)=O
Molecular Formula
C27H36N2O3S
Molecular Weight
468.65
References & Citations
[1]Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TREM-2
Available Sizes
Curated Selection
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