EZH2-IN-23
EZH2-IN-23 (Compound 25) is an EZH2 inhibitor that exhibits potent enzymatic inhibition of the PRC2 complex (EZH2, EED, SUZ12, AEBP2, RbAp48) with a biochemical IC50 of 0.8 nM. EZH2-IN-23 inhibits H3K27 trimethylation in cellular assays, showing an IC50 of 40 nM. EZH2-IN-23 displays good rat PKproperties with 100 % oral bioavailability[1].
Product Specifications
CAS Number
3095068-20-2
UNSPSC
12352100
Target
Histone Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(N1)=CC(C)=C(CN2CCC(SC([C@H](C)C3CCN(CC4=NC=C(Cl)C=C4)CC3)=C5C)=C5C2=O)C1=O
Molecular Formula
C29H35ClN4O2S
Molecular Weight
539.13
References & Citations
[1]Tian X, et, al. Asymmetric synthesis of potent and orally bioavailable thiophene-based EZH2 inhibitors. Bioorg Med Chem Lett. 2025 May 30;127:130291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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