INNO-220
INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1].
Product Specifications
CAS Number
3032576-92-1
UNSPSC
12352005
Target
Casein Kinase; MALT1; MDM-2/p53; Molecular Glues
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; PROTAC; Stem Cell/Wnt
Field of Research
Cancer
Purity
98.60
Solubility
DMSO : 2.5 mg/mL (ultrasonic)
Smiles
CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5
Molecular Formula
C23H20N4O3
Molecular Weight
400.43
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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