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INNO-220

INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1].

Product Specifications

CAS Number

3032576-92-1

UNSPSC

12352005

Target

Casein Kinase; MALT1; MDM-2/p53; Molecular Glues

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; PROTAC; Stem Cell/Wnt

Field of Research

Cancer

Purity

98.60

Solubility

DMSO : 2.5 mg/mL (ultrasonic)

Smiles

CN1N=CC(C2=CC3=C(C(N(C3)C4CCC(NC4=O)=O)=O)C=C2)=C1C5=CC=CC=C5

Molecular Formula

C23H20N4O3

Molecular Weight

400.43

References & Citations

[1]Shi Feng, et al. A highly selective and orally bioavailable casein kinase 1 alpha degrader through p53 signaling pathway targets B-cell lymphoma cells. Leukemia. 2025 May 27.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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