PROTAC EML4-ALK Degrader-1
PROTAC EML4-ALK Degrader-2 (Pro-BA) is a selective and orally active linker-free EML4-ALK PROTAC degrader with the DC50 of 74 nM in H1322 cells (T1/2 = 8 h). PROTAC EML4-ALK Degrader-2 relies on GID4 and proteasome pathways to promote ubiquitination of target proteins, leading to cell apoptosis. PROTAC EML4-ALK Degrader-2 can be used for research on cancer. (Pink: EML4-ALK Ligand ; Blue: GID4 Ligand (HY-150908) )
Product Specifications
Product Name Alternative
Pro-BA
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; PROTACs
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(C=CC(N2CCN(CC2)C([C@H]3CCCN3)=O)=C1)NC4=NC=C(C(NC5=CC=CC=C5P(C)(C)=O)=N4)Cl
Molecular Formula
C28H35ClN7O3P
Molecular Weight
584.05
References & Citations
[1]Zhang J, et al. Linker-free PROTACs efficiently induce the degradation of oncoproteins. Nat Commun. 2025 May 23;16 (1) :4794.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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