HPK1 ligand 3
HPK1 ligand 3 is a ligand for target protein for PROTAC that can be used to synthesize PROTAC HPK1 Degrader-4 (HY-174135) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; MAP4K
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
BrC1=NC2=C(N=C1)N(C(OC(C)(C)C)=O)C=C2C3=CC(C)=C(C=C3)C(N(C)C)=O
Molecular Formula
C21H23BrN4O3
Molecular Weight
459.34
References & Citations
[1]Wu M, et al. Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation. J Med Chem. 2025 Jun 12;68 (11) :10800-10822.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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