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CYP51-IN-23-d3

CYP51-IN-23-d3 is a potent and broad-spectrum CYP51 inhibitor with a MIC80 of 1 μg/mL against Aspergillus fumigatum. CYP51-IN-23-d3 can prevent fungal phase transformation and biofilm formation. CYP51-IN-23-d3 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-23-d3 can be used for the study of invasive fungal infections (IFIs) [1].

Product Specifications

UNSPSC

12352005

Target

Cytochrome P450; Fungal; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

FC1=CC(F)=CC=C1C(CN(C([2H])([2H])[2H])CC2=CC=C(N3CCN(C(C4=CC(Br)=CC=C4)=O)CC3)C=C2)(O)CN5C=NN=N5

Molecular Formula

C29H27D3BrF2N7O2

Molecular Weight

629.51

References & Citations

[1]Luo Z et al. Discovery of a potent, broad-spectrum and in vivo effective deuterated tetrazole CYP51 inhibitor. Eur J Med Chem. 2025 May 28;296:117817.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

CYP51

Frequently Asked Questions

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