TERT ligand-1
TERT ligand-1 is a PROTAC target protein ligand that can be used to synthesize the PROTAC NU-PRO-1 (HY-174351) . NU-PRO-1 induces TERT degradation in cancer cells[1].
Product Specifications
CAS Number
[2412120-47-7]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; Telomerase
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C([C@](C1=O)(C)[C@H](CCC2=CN(CC3=CC=C(F)C=C3F)N=N2)O[C@H](C)C1=C)OC
Molecular Formula
C21H23F2N3O4
Molecular Weight
419.42
References & Citations
[1]Frost GB, et al. Telomerase reverse transcriptase degradation via a rationally designed covalent proteolysis targeting chimera. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130286.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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